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Clinically, OA management predominantly focuses on symptom relief and surgical intervention, underscoring the urgent need to explore its underlying mechanisms and identify new therapeutic targets (Loughlin, 2022

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Briefly, the PPI session started with a 5-min habituation period, in which only a background noise (BN) of 7273 dB was presented, followed by 5 consecutive startle trials, which were excluded from the statistical analysis, and 9 different trial types were repeated 10 times in random order and with an intertrial interval of 25 s on average